Present study deals with the study of okra mucilage as sustain release excipient in transdermal formulation. Mucilage was extracted using water based extraction method, the yield of mucilage was found to be 9.83 gm/kg. Characterization of the extracted mucilage was done by various parameters such as micromeritic studies, flow behaviour, solubility, pH and organoleptic properties. Various transdermal patches of itraconazole were prepared by solvent evaporation technique using different proportions of okra mucilage and glycerin as plasticizer and polyethylene glycol-400 as permeation enhancer. The compatibility studies between itraconazole and okra mucilage revealed that there were no negative interactions between itraconazole and okra mucilage. Formulated transdermal films were physically evaluated with regard to thickness, physical appearance, weight variation, drug content, folding endurance, percentage of moisture content and elongation break. All prepared formulations indicated good physical stability. In-vitro permeation studies of formulations were performed by using Franz diffusion cells. The experimental results shows that the drug release from the patches delayed in controlled manner as the proportion of okra mucilage increased. The stability studies proved that the formulated patches were stable at stressed storage conditions. It was concluded that okra mucilage can be used as polymer for making transdermal patches.
Loading....